(1) Background: Tauopathies are a group of diseases characterized by the deposition of abnormal tau protein. They are distinguished into 3R, 4R, and 3R/4R tauopathies and also include Alzheimer's disease (AD) and chronic traumatic encephalopathy (CTE). Positron emission tomography (PET) imaging represents a pivotal instrument to guide clinicians. This systematic review aims to summarize the current and novel PET tracers. (2) Methods: Literature research was conducted on Pubmed, Scopus, Medline, Central, and the Web of Science using the query "pet ligands" and "tauopathies". Articles published from January 2018 to 9 February, 2023, were searched. Only studies on the development of novel PET radiotracers for imaging in tauopathies or comparative studies between existing PET tracers were included. (3) Results: A total of 126 articles were found, as follows: 96 were identified from PubMed, 27 from Scopus, one on Central, two on Medline, and zero on the Web of Science. Twenty-four duplicated works were excluded, and 63 articles did not satisfy the inclusion criteria. The remaining 40 articles were included for quality assessment. (4) Conclusions: PET imaging represents a valid instrument capable of helping clinicians in diagnosis, but it is not always perfect in differential diagnosis, even if further investigations on humans for novel promising ligands are needed.

Imaging of tauopathies with PET ligands: state of the art and future outlook / Conte, Miriam; De Feo, Maria Silvia; Sidrak, Marko Magdi Abdou; Corica, Ferdinando; Gorica, Joana; Granese, Giorgia Maria; Filippi, Luca; De Vincentis, Giuseppe; Frantellizzi, Viviana. - In: DIAGNOSTICS. - ISSN 2075-4418. - 13:10(2023). [10.3390/diagnostics13101682]

Imaging of tauopathies with PET ligands: state of the art and future outlook

Conte, Miriam
Primo
;
De Feo, Maria Silvia
Secondo
;
Sidrak, Marko Magdi Abdou;Corica, Ferdinando;Gorica, Joana;Granese, Giorgia Maria;De Vincentis, Giuseppe
Penultimo
;
Frantellizzi, Viviana
Ultimo
2023

Abstract

(1) Background: Tauopathies are a group of diseases characterized by the deposition of abnormal tau protein. They are distinguished into 3R, 4R, and 3R/4R tauopathies and also include Alzheimer's disease (AD) and chronic traumatic encephalopathy (CTE). Positron emission tomography (PET) imaging represents a pivotal instrument to guide clinicians. This systematic review aims to summarize the current and novel PET tracers. (2) Methods: Literature research was conducted on Pubmed, Scopus, Medline, Central, and the Web of Science using the query "pet ligands" and "tauopathies". Articles published from January 2018 to 9 February, 2023, were searched. Only studies on the development of novel PET radiotracers for imaging in tauopathies or comparative studies between existing PET tracers were included. (3) Results: A total of 126 articles were found, as follows: 96 were identified from PubMed, 27 from Scopus, one on Central, two on Medline, and zero on the Web of Science. Twenty-four duplicated works were excluded, and 63 articles did not satisfy the inclusion criteria. The remaining 40 articles were included for quality assessment. (4) Conclusions: PET imaging represents a valid instrument capable of helping clinicians in diagnosis, but it is not always perfect in differential diagnosis, even if further investigations on humans for novel promising ligands are needed.
2023
Alzheimer’s disease; MAPT; PET imaging; PiB; TSPO; amyloid plaque; tau PET; tauopathies
01 Pubblicazione su rivista::01g Articolo di rassegna (Review)
Imaging of tauopathies with PET ligands: state of the art and future outlook / Conte, Miriam; De Feo, Maria Silvia; Sidrak, Marko Magdi Abdou; Corica, Ferdinando; Gorica, Joana; Granese, Giorgia Maria; Filippi, Luca; De Vincentis, Giuseppe; Frantellizzi, Viviana. - In: DIAGNOSTICS. - ISSN 2075-4418. - 13:10(2023). [10.3390/diagnostics13101682]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1685160
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